Current concept of the pathogenesis of preeclampsia involve the maternal vascular endothelial dysfunction. We measured the plasma fibronectin as a maker of endothelial cell dysfunction.
To evaluate the effects of preeclampsia and delivery, the plasma fibronection level was measured before and 48 hours after delivery in 86 pregnant woman.
25 patients with mild preeclampsia and 24 patients with severe preeclampsia were compared with the pregnant control patients.
@ES Followings are the results summarized.
@EN 1. The mean levels of plasma fibronectin before delivery in normal pregnant, mild preeclampsia, severe preeclampsia women were 118.9±19mg/dl, 294.8±24.1mg/dl, and 453.6±18.7mg/dl, respectively.
2. The mean levels of plasma fibronectin 48 hours after delivery in normal pregnant women, mild preeclampsia, severe preeclampsia, severe preeclampsia were 102.8±15.1mg/dl, 186.3±19.3mg/dl, and 268.7±23.4mg/dl, respectively.
3. The mean levels of plasma fibronectin revels were higher in preeclampsia women than normal pregnant women before delivery and rapid decreased plasma fibronectin levels were noted only in preeclampsia patients.
Preeclampsia was associated with high fibronectin level (p<0.01) suggesting vascular endothelial cell dysfunction. 48 hours after delivery, decreased plasma fibronectin level was noted in mild and severe preeclampsia patients (p<0.001).
Vascular endothelial cell dysfunction in preeclampsia appeared to resolve soon after delivery, which would contribute to the rapid clinical improvement noted in early puerperium.
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